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Inactivation of HIV by nonoxynol Comparison of condom breakage during human use with performance in laboratory testing. Mineral oil lubricants cause rapid deterioration of latex condoms. Oral-penile contact fellatio is not an efficient route of HIV infection. Given the importance of sexual transmission in the HIV epidemic, many HIV prevention strategies have focused on identifying and promoting safer-sex practices. Oral-Vaginal Sex The risk of HIV transmission through oral-vaginal sex cunnilingus has received less attention than oral-penile sex.